Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.40 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.40 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707949 | 0.85 | TPSAB1 (0.44) | SYKPOLBTPSAB1TPSD1TPSG1 | |
| SCHEMBL19339724 | 0.85 | TPSAB1 (0.44) | SYKPOLBTPSAB1TPSD1TPSG1 | |
| SCHEMBL9977210 | 0.80 | ITGA4 (0.40) | HDAC3HDAC1HDAC2NCOR2SMN1; SMN2 | |
| SCHEMBL7410587 | 0.76 | L3MBTL1 (0.43) | SYKPOLBTPSAB1TPSD1TPSG1 | |
| SCHEMBL27963815 | 0.76 | CTSK (0.50) | SYKL3MBTL1MAPT | |
| SCHEMBL9773175 | 0.74 | HSD17B10 (0.44) | POLBL3MBTL1SMN1; SMN2LMNAMAPT | |
| SCHEMBL9773237 | 0.74 | HSD17B10 (0.44) | POLBL3MBTL1SMN1; SMN2LMNAMAPT | |
| SCHEMBL2137272 | 0.74 | POLB (0.49) | SYKPOLBL3MBTL1MAPT | |
| SCHEMBL2134853 | 0.74 | POLB (0.49) | SYKPOLBL3MBTL1MAPT | |
| SCHEMBL2134843 | 0.74 | POLB (0.49) | SYKPOLBL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651623-B1 | HEXAHYDRODIAZEPINONES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2008-12-17 | — | — | EP | disclosed |