Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1336811 | 0.80 | P2RX3 (0.32) | P2RX3 | |
| SCHEMBL4760890 | 0.73 | HSD11B1 (0.34) | HPGDKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL1338855 | 0.69 | — | — | |
| SCHEMBL1337155 | 0.64 | DPP4 (0.34) | HPGDL3MBTL1KDM4ENPSR1P2RX3 | |
| SCHEMBL12126157 | 0.64 | KDM4C (0.41) | L3MBTL1P2RX3MEN1NPC1RAB9A | |
| SCHEMBL2385112 | 0.63 | P2RX3 (0.39) | P2RX3 | |
| SCHEMBL1338170 | 0.63 | ATR (0.37) | P2RX3 | |
| SCHEMBL3522758 | 0.62 | MEN1 (0.35) | L3MBTL1P2RX3MEN1NPC1RAB9A | |
| SCHEMBL1339414 | 0.61 | GABRG2 (0.43) | HPGDKDM4EALDH1A1 | |
| SCHEMBL7243739 | 0.60 | KDM4C (0.39) | L3MBTL1MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |