Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760637 | 0.77 | SRC (0.48) | KMT2AMEN1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL4760596 | 0.75 | MAPK14 (0.52) | KMT2AMEN1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL4761086 | 0.70 | EGFR (0.43) | KMT2AMEN1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL1338158 | 0.67 | GSK3B (0.43) | KMT2AMEN1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL1337392 | 0.66 | HSD17B10 (0.46) | KMT2AMEN1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL27742629 | 0.66 | MAPK14 (0.49) | KMT2AMEN1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL7486124 | 0.63 | ALDH1A1 (0.62) | KMT2AMEN1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL15024745 | 0.63 | GPR3 (0.64) | KMT2AMEN1KDM4EMAPTGAA | |
| SCHEMBL17025696 | 0.62 | SMN1; SMN2 (0.67) | KMT2AKDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL9835058 | 0.61 | WEE1 (0.64) | SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |