Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760637 | 0.88 | SRC (0.48) | MAPK14EGFRSRCKMT2AALDH1A1 | |
| SCHEMBL27742629 | 0.78 | MAPK14 (0.49) | MAPK14KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4761086 | 0.78 | EGFR (0.43) | EGFRSRCKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4760559 | 0.75 | KMT2A (0.44) | MAPK14EGFRSRCKMT2AALDH1A1 | |
| SCHEMBL14288833 | 0.70 | ALDH1A1 (0.66) | EGFRSRCKMT2AALDH1A1LMNA | |
| SCHEMBL1336997 | 0.69 | MAPK14 (0.49) | MAPK14KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4760594 | 0.68 | AHR (0.38) | MAPK14KMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7486679 | 0.66 | ALDH1A1 (0.58) | EGFRALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL8999220 | 0.66 | SRC (1.00) | EGFRSRCALDH1A1 | |
| SCHEMBL15024745 | 0.66 | GPR3 (0.64) | EGFRSRCKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |