Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762615 | 0.88 | ALDH1A1 (0.45) | RXFP1KDM4ENPSR1ALDH1A1MAPK1 | |
| SCHEMBL4523252 | 0.84 | HTT (0.52) | HTTRXFP1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL6706191 | 0.83 | ALDH1A1 (0.45) | RXFP1KDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL4891790 | 0.82 | ALDH1A1 (0.41) | KDM4EALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL4762728 | 0.78 | MAPT (0.39) | KDM4ENPSR1ALDH1A1MAPK1MEN1 | |
| SCHEMBL3259352 | 0.76 | KDM4E (0.56) | RXFP1KDM4ENPSR1ALDH1A1MAPK1 | |
| SCHEMBL4896130 | 0.76 | ALDH1A1 (0.53) | HTTRXFP1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL4718237 | 0.71 | PDE4A (0.40) | HTTKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL4760642 | 0.71 | ALDH1A1 (0.40) | RXFP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4761421 | 0.71 | ALDH1A1 (0.42) | RXFP1KDM4ENPSR1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458722-B1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2008-10-15 | — | — | EP | disclosed |
| EP-1458722-A1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GmbH (DE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055882-A1 | PYRROLOPYRIMIDINES AS PHOSPHODIESTERASE VII INHIBITORS | MERCK PATENT GMBH (DE) | 2003-07-10 | — | — | WO | disclosed |