Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11339280 | 0.82 | KDM4E (0.54) | KDM4ENPSR1RXFP1ALDH1A1HPGD | |
| SCHEMBL11340384 | 0.82 | ALDH1A1 (0.57) | KDM4ENPSR1RXFP1ALDH1A1HPGD | |
| SCHEMBL11335662 | 0.81 | L3MBTL1 (0.44) | KDM4ENPSR1RXFP1ALDH1A1HPGD | |
| SCHEMBL4523252 | 0.79 | HTT (0.52) | KDM4ENPSR1RXFP1ALDH1A1HPGD | |
| SCHEMBL11494325 | 0.78 | HTT (0.38) | KDM4ENPSR1RXFP1ALDH1A1HPGD | |
| SCHEMBL4760669 | 0.76 | HTT (0.44) | KDM4ENPSR1RXFP1ALDH1A1HPGD | |
| SCHEMBL11345308 | 0.75 | ALDH1A1 (0.56) | KDM4ENPSR1RXFP1ALDH1A1HPGD | |
| SCHEMBL3162626 | 0.74 | MEN1 (0.42) | KDM4ENPSR1RXFP1ALDH1A1HPGD | |
| SCHEMBL11340409 | 0.73 | KDM4E (0.49) | KDM4ENPSR1RXFP1ALDH1A1HPGD | |
| SCHEMBL11347779 | 0.72 | NOTUM (0.34) | KDM4ENPSR1RXFP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756110-B1 | 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES, AS WELL AS THEIR THERAPEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR PRODUCTION THE ACTIVE AGENT | SZOLCSANYI JANOS (HU) | 2010-03-31 | — | — | EP | disclosed |
| US-20080214583-A1 | 7H-Pyrrolo[2,3-D]Pyrimidine Derivatives, As Well As Their Therapeutically Acceptable Salts, Pharmaceutical Preparations Containing Them And Process For Production The Active Agent | SZOLCSANYI JANOS | 2008-09-04 | — | — | US | disclosed |
| EP-0005205-B1 | SUBSTITUTED 5.6-DIMETHYLPYRROLO(2,3-D)PYRIMIDINES, METHODS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | Troponwerke GmbH & Co. KG (DE) | 1981-09-09 | — | — | EP | disclosed |
| US-4229453-A | ANTIINFLAMMATORY AGENTS, SEDATIVES, ANTICONVULSANTS | BAYER AKTIENGESELLSCHAFT (DE) | 1980-10-21 | — | — | US | disclosed |
| EP-0005205-A1 | Substituted 5.6-dimethylpyrrolo(2,3-d)pyrimidines, methods for their preparation and medicines containing them | Troponwerke GmbH & Co. KG (DE) | 1979-11-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214583-A1 | 7H-Pyrrolo[2,3-D]Pyrimidine Derivatives, As Well As Their Therapeutically Acceptable Salts, Pharmaceutical Preparations Containing Them And Process For Production The Active Agent | TYMS, DPYD, P2RX7 | KDM4E 2960/4885NPSR1 252/4885RXFP1 3790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.