Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | EIF4E | P06730 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 5/20 | 0.33 |
| ▸ | CNR2 | P34972 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1339112 | 0.86 | RAB9A (0.61) | NPC1RAB9ATDP1L3MBTL1MAPT | |
| SCHEMBL1340004 | 0.81 | LTA4H (0.43) | NPC1RAB9AMAPTKDM4EGAA | |
| SCHEMBL1339304 | 0.81 | PTGS2 (0.39) | NPC1RAB9ATDP1L3MBTL1MAPT | |
| SCHEMBL1336992 | 0.78 | RAB9A (0.55) | NPC1RAB9ATDP1L3MBTL1MAPT | |
| SCHEMBL1338029 | 0.78 | GABRA1 (0.41) | NPC1RAB9ATDP1L3MBTL1MAPT | |
| SCHEMBL1338126 | 0.77 | L3MBTL1 (0.61) | NPC1RAB9ATDP1L3MBTL1MAPT | |
| SCHEMBL1339111 | 0.76 | RAB9A (0.44) | NPC1RAB9ATDP1L3MBTL1MAPT | |
| SCHEMBL1339176 | 0.76 | EIF4E (0.39) | NPC1RAB9AMAPTKDM4EGAA | |
| SCHEMBL1339161 | 0.74 | EIF4E (0.39) | NPC1RAB9AKDM4EGAAGABRA1 | |
| SCHEMBL1339284 | 0.74 | EIF4E (0.37) | NPC1RAB9AKDM4EGAAGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |