Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1368664 | 0.66 | KDM4E (0.37) | ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL11093397 | 0.65 | DRD2 (0.70) | ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL4764889 | 0.64 | ACACA (0.37) | ALDH1A1KDM4EHTTKMT2AACACA | |
| SCHEMBL27625186 | 0.63 | ALDH1A1 (0.52) | ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL9819832 | 0.63 | MEN1 (0.68) | ALDH1A1KDM4ESMN1; SMN2KMT2AATM | |
| SCHEMBL27883981 | 0.62 | KDM4E (0.56) | ALDH1A1KDM4ESMN1; SMN2HTTTSHR | |
| SCHEMBL4466600 | 0.61 | ALDH1A1 (0.59) | ALDH1A1KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1684895 | 0.61 | — | — | |
| SCHEMBL10985089 | 0.61 | ALDH1A1 (0.72) | ALDH1A1KDM4ESMN1; SMN2HTTKMT2A | |
| SCHEMBL7475308 | 0.61 | ALDH1A1 (0.70) | ALDH1A1KDM4ESMN1; SMN2CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432715-B1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-03-19 | — | — | EP | disclosed |
| US-7312224-B2 | Pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2007-12-25 | — | — | US | disclosed |
| US-20040242595-A1 | Pyrimidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242595-A1 | Pyrimidine derivatives | TYMP, DPYD, TYMS | ALDH1A1 671/4885KDM4E 2620/4885KCNH2 928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.