Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819725 | 0.94 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL9819832 | 0.88 | MEN1 (0.68) | ALDH1A1KDM4EPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL317705 | 0.87 | ADORA3 (0.57) | ALDH1A1KDM4EPOLBSMN1; SMN2MAPK1 | |
| SCHEMBL22122723 | 0.86 | ALDH1A1 (0.57) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL11093397 | 0.86 | DRD2 (0.70) | ALDH1A1KDM4EPOLBSMN1; SMN2TSHR | |
| SCHEMBL10735376 | 0.86 | ALDH1A1 (0.64) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL4466600 | 0.85 | ALDH1A1 (0.59) | ALDH1A1KDM4EPOLBSMN1; SMN2HSD17B10 | |
| SCHEMBL8472994 | 0.84 | LMNA (0.60) | ALDH1A1KDM4EPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL7658562 | 0.84 | L3MBTL1 (0.68) | ALDH1A1POLBL3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL587589 | 0.84 | ALDH1A1 (0.62) | ALDH1A1KDM4EPOLBL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059969-A1 | PIPERAZINES AS ANTI-OBESITY AGENTS | ASTRAZENECA AB (SE) | 2011-03-10 | — | — | US | disclosed |
| US-20110046135-A1 | NEW COMPOUNDS I | ASTRAZENECA AB (PUBL) (SE) | 2011-02-24 | — | — | US | disclosed |
| WO-1997044334-A2 | NOVEL PIPERAZINE OR HOMOPIPERAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THEIR PREPARATION | EGIS Gyógyszergyár Rt. (HU) | 1997-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046135-A1 | NEW COMPOUNDS I | GPR119, GLP1R, FABP4 | ALDH1A1 2089/4885KDM4E 3535/4885POLB 3624/4885 |
| US-20110059969-A1 | PIPERAZINES AS ANTI-OBESITY AGENTS | GPR119, FABP4, ADIPOR2 | ALDH1A1 1389/4885KDM4E 1707/4885POLB 2874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.