Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 10/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763460 | 0.80 | KDM4E (0.41) | MAPTLMNATHRBKDM4EALDH1A1 | |
| SCHEMBL4769340 | 0.69 | THRB (0.40) | THRB | |
| SCHEMBL1078049 | 0.61 | ALDH1A1 (0.57) | MAPTLMNAALDH1A1HSD17B10GAA | |
| SCHEMBL4640870 | 0.61 | — | — | |
| SCHEMBL9330353 | 0.60 | SCN1A (0.49) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8375449 | 0.60 | ALDH1A1 (0.50) | LMNATHRBALDH1A1HSD17B10GAA | |
| SCHEMBL305155 | 0.60 | ALDH1A1 (0.50) | LMNATHRBKDM4EALDH1A1TSHR | |
| SCHEMBL6206254 | 0.59 | ALDH1A1 (0.51) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL5036740 | 0.59 | CHRM1 (0.46) | MAPTLMNATHRBKDM4EALDH1A1 | |
| SCHEMBL8552607 | 0.58 | BCHE (0.35) | MAPTLMNAALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432715-B1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1432715-A2 | PYRIMIDINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003031447-A2 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-04-17 | — | — | WO | disclosed |