SCHEMBL476303

SCHEMBL476303

COC(=O)[C@H]1CCC(=O)N1C(=O)OC(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.41
CHRM2 P08172 1/20 0.40
CHRM1 P11229 1/20 0.40
CHRM3 P20309 1/20 0.40
WNT3 P56703 1/20 0.39
SFRP1 Q8N474 1/20 0.39
PTPN1 P18031 2/20 0.38
BRD4 O60885 1/20 0.37
MMP2 P08253 1/20 0.37
ANPEP P15144 1/20 0.37
MEN1 O00255 1/20 0.36
NR1H2 P55055 1/20 0.36
NR1H3 Q13133 1/20 0.36
ALDH1A1 P00352 1/20 0.36
ELANE P08246 1/20 0.35
PDE4B Q07343 1/20 0.35
ACE P12821 2/20 0.35
EPHX1 P07099 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL476304 1.00 KMT2A (0.41) KMT2ACHRM2CHRM1CHRM3WNT3
SCHEMBL540990 1.00 KMT2A (0.41) KMT2ACHRM2CHRM1CHRM3WNT3
SCHEMBL1604617 0.91 MMP2 (0.38) KMT2ACHRM2CHRM1CHRM3WNT3
SCHEMBL1604618 0.91 MMP2 (0.38) KMT2ACHRM2CHRM1CHRM3WNT3
SCHEMBL18018362 0.91 MMP2 (0.38) KMT2ACHRM2CHRM1CHRM3WNT3
SCHEMBL713924 0.91 CHRM2 (0.41) CHRM2CHRM1CHRM3WNT3SFRP1
SCHEMBL1372911 0.91 CHRM2 (0.41) CHRM2CHRM1CHRM3WNT3SFRP1
SCHEMBL12105456 0.91 CHRM2 (0.41) CHRM2CHRM1CHRM3WNT3SFRP1
SCHEMBL30289778 0.91 CHRM2 (0.41) CHRM2CHRM1CHRM3WNT3SFRP1
SCHEMBL6743320 0.88 CHRM2 (0.38) CHRM2CHRM1CHRM3WNT3SFRP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114920771-A Novel synthesis process of intermediate of novel oral medicine for overactive bladder 苏州虞美景盛新药开发有限公司 2022-08-19 CN claimed
EP-4688766-A1 HETEROCYCLOALKYL BETA-HYDROXY ALKYL AMINES FOR USE IN THE TREATMENT OF HYPERGLYCAEMIA AND DISORDERS CHARACTERISED BY HYPERGLYCAEMIA Atrogi AB (SE) 2026-02-11 EP disclosed
EP-4676929-A1 PROTAC DEGRADERS OF MLLT1 AND/OR MLLT3 Dark Blue Therapeutics Ltd (GB) 2026-01-14 EP disclosed
US-20250368646-A1 TRICYCLIC FUSED WRN INHIBITORS NIMBUS WADJET INC (US) 2025-12-04 US disclosed
EP-4638447-A1 IMIDAZO[1,2-A]PYRIDINE AND IMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS MLLT1 AND MLLT3 INHIBITORS Dark Blue Therapeutics Ltd (GB) 2025-10-29 EP disclosed
US-12378216-B2 Heteroaryl(heterocyclyl)methanol compounds useful in the treatment of hyperglycaemia ATROGI AB (SE) 2025-08-05 US disclosed
US-20240391871-A1 SUBSTITUTED HYDROXYMETHYL PYRROLIDINES AND MEDICAL USES THEREOF ATROGI AB (SE) 2024-11-28 US disclosed
WO-2024234360-A1 TETRACYCLIC DERIVATIVES AS KRAS INHIBITORS NIKANG THERAPEUTICS , INC. (US) 2024-11-21 WO disclosed
WO-2024200777-A1 SUBSTITUTED HYDROXYMETHYL PYRROLIDINES FOR USE IN THE TREATMENT OF HYPERGLYCAEMIA AND DISORDERS CHARACTERISED BY HYPERGLYCAEMIA ATROGI AB (SE) 2024-10-03 WO disclosed
WO-2024200780-A1 HETEROCYCLOALKYL BETA-HYDROXY ALKYL AMINES FOR USE IN THE TREATMENT OF HYPERGLYCAEMIA AND DISORDERS CHARACTERISED BY HYPERGLYCAEMIA ATROGI AB (SE) 2024-10-03 WO disclosed
EP-2411000-A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2012-02-01 EP disclosed
EP-2349244-A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2011-08-03 EP disclosed
WO-2011044057-A1 SULFONAMIDO PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2011-04-14 WO disclosed
WO-2010110817-A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2010-09-30 WO disclosed
WO-2010042892-A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2010-04-15 WO disclosed
US-7256186-B2 Gamma secretase inhibitors SCHERING CORPORATION (US) 2007-08-14 US disclosed
EP-1663975-A1 NOVEL GAMMA SECRETASE INHIBITORS SCHERING CORPORATION (US) 2006-06-07 EP disclosed
US-20050085506-A1 Novel gamma secretase inhibitors SCHERING-PLOUGH CORPORATION AND PHARMACOPEIA, INC. 2005-04-21 US disclosed
WO-2005028440-A1 NOVEL GAMMA SECRETASE INHIBITORS SCHERING CORPORATION (US) 2005-03-31 WO disclosed
US-20040171614-A1 Novel gamma secretase inhibitors SCHERING-PLOUGH CORPORATION 2004-09-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040171614-A1 Novel gamma secretase inhibitors BACE1, BACE2, APP KMT2A 3318/4885CHRM2 1541/4885CHRM1 1139/4885
US-20240391871-A1 SUBSTITUTED HYDROXYMETHYL PYRROLIDINES AND MEDICAL USES THEREOF CYP3A5, PRMT5, CYP11B2 KMT2A 1562/4885CHRM2 1576/4885CHRM1 965/4885
US-12378216-B2 Heteroaryl(heterocyclyl)methanol compounds useful in the treatment of hyperglycaemia SLC5A1, GPR119, SLC5A2 KMT2A 1713/4885CHRM2 353/4885CHRM1 145/4885
US-20050085506-A1 Novel gamma secretase inhibitors BACE1, BACE2, APP KMT2A 2232/4885CHRM2 338/4885CHRM1 295/4885
US-20250368646-A1 TRICYCLIC FUSED WRN INHIBITORS WRN, BLM, RECQL KMT2A 2754/4885CHRM2 4787/4885CHRM1 4751/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.