Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.34 |
| ▸ | JUN | P05412 | 2/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765932 | 0.85 | STK17B (0.43) | STK17BSTK17ASYKPOLBAPEX1 | |
| SCHEMBL4768852 | 0.84 | ALDH1A1 (0.46) | STK17BSTK17ASYKPOLBAPEX1 | |
| SCHEMBL4765257 | 0.84 | STK17B (0.47) | STK17BSTK17AKDM4EL3MBTL1NFKB1 | |
| SCHEMBL4774497 | 0.83 | NFKB1 (0.40) | STK17BSTK17ASYKPOLBAPEX1 | |
| SCHEMBL4769101 | 0.82 | STK17B (0.43) | STK17BSTK17ASYKPOLBAPEX1 | |
| SCHEMBL4772216 | 0.80 | STK17B (0.40) | STK17BSTK17AMEN1KMT2ASYK | |
| SCHEMBL4772853 | 0.80 | TRPA1 (0.41) | STK17BSTK17ASYKPOLBAPEX1 | |
| SCHEMBL4773876 | 0.80 | NFKB1 (0.40) | STK17BSTK17ASYKPOLBAPEX1 | |
| SCHEMBL4768083 | 0.80 | STK17B (0.40) | STK17BSTK17ASYKPOLBAPEX1 | |
| SCHEMBL4769948 | 0.79 | STK17B (0.46) | STK17BSTK17AKDM4EL3MBTL1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |