Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765257 | 0.87 | STK17B (0.47) | STK17BSTK17AJAK3KDM4ENPSR1 | |
| SCHEMBL4768852 | 0.85 | ALDH1A1 (0.46) | STK17BSTK17AJAK3ALDH1A1HPGD | |
| SCHEMBL4774497 | 0.82 | NFKB1 (0.40) | STK17BSTK17AALDH1A1LRRK2JUN | |
| SCHEMBL4765932 | 0.81 | STK17B (0.43) | STK17BSTK17AALDH1A1LRRK2JUN | |
| SCHEMBL4769101 | 0.81 | STK17B (0.43) | STK17BSTK17ALMNAJAK3ALDH1A1 | |
| SCHEMBL4769049 | 0.80 | L3MBTL1 (0.48) | STK17BSTK17ALMNAALDH1A1KDM4E | |
| SCHEMBL4763606 | 0.79 | STK17B (0.41) | STK17BSTK17AKDM4EL3MBTL1LRRK2 | |
| SCHEMBL4770559 | 0.77 | JAK2 (0.43) | JAK3TYRO3MERTK | |
| SCHEMBL4772216 | 0.76 | STK17B (0.40) | STK17BSTK17AALDH1A1HTTLRRK2 | |
| SCHEMBL4772853 | 0.76 | TRPA1 (0.41) | STK17BSTK17AJAK3LRRK2JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |