Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | COMT | P21964 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4126123 | 0.94 | NAMPT (0.35) | PKMHTR6KMT2APTGDR2 | |
| SCHEMBL3702686 | 0.90 | HTR6 (0.40) | HTR6 | |
| SCHEMBL476470 | 0.88 | HTR6 (0.36) | HTR6KMT2ALIMK2L3MBTL1 | |
| SCHEMBL476325 | 0.87 | HTR2C (0.42) | HTR6COMTKMT2APTGDR2KDM4E | |
| SCHEMBL18258907 | 0.87 | HTR6 (0.32) | HTR6KMT2AKDM4EMAPT | |
| SCHEMBL476326 | 0.86 | COMT (0.36) | PKMHTR6COMTKMT2APTGDR2 | |
| SCHEMBL4125764 | 0.85 | NFE2L2 (0.40) | — | |
| SCHEMBL476365 | 0.85 | APLNR (0.35) | PTGDR2KCNA5 | |
| SCHEMBL476288 | 0.84 | COMT (0.41) | PKMHTR6COMTKDM4EMAPT | |
| SCHEMBL4135832 | 0.83 | SLC16A3 (0.36) | PKMHTR6PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2412713-B1 | PYRAZOLE COMPOUND | TAKEDA PHARMACEUTICAL (JP) | 2016-11-30 | — | — | EP | disclosed |
| EP-2412713-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2012-02-01 | — | — | EP | disclosed |