Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765891 | 0.78 | CSNK1A1 (0.51) | CSNK1A1CLK4KDM4EALDH1A1PIN1 | |
| SCHEMBL15434051 | 0.77 | TDP1 (0.44) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL4773492 | 0.75 | CSNK1A1 (0.45) | CSNK1A1CLK4KDM4EALDH1A1MAPK1 | |
| SCHEMBL12929767 | 0.74 | ACP1 (0.51) | CLK4KDM4EALDH1A1TDP1MAPK1 | |
| SCHEMBL4769052 | 0.74 | CSNK1A1 (0.44) | CSNK1A1CLK4PIN1AR | |
| SCHEMBL4763570 | 0.74 | CSNK1A1 (0.44) | CSNK1A1CLK4ALDH1A1L3MBTL1PIN1 | |
| SCHEMBL13649069 | 0.74 | KMT2A (0.52) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL27826456 | 0.74 | CSNK1A1 (0.55) | CSNK1A1CLK4KDM4EALDH1A1TDP1 | |
| SCHEMBL4773830 | 0.73 | CSNK1A1 (0.43) | CSNK1A1CLK4ALDH1A1PIN1AR | |
| SCHEMBL4773917 | 0.71 | ALDH1A1 (0.42) | CSNK1A1CLK4KDM4EALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |