Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | NMT1 | P30419 | 6/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773830 | 0.83 | CSNK1A1 (0.43) | CSNK1A1CLK4PIN1ARGBA1 | |
| SCHEMBL4763570 | 0.78 | CSNK1A1 (0.44) | CSNK1A1CLK4PIN1ARALDH1A1 | |
| SCHEMBL4769052 | 0.78 | CSNK1A1 (0.44) | CSNK1A1CLK4PIN1AR | |
| SCHEMBL4765891 | 0.76 | CSNK1A1 (0.51) | CSNK1A1CLK4PIN1KDM4EALDH1A1 | |
| SCHEMBL4764036 | 0.75 | CSNK1A1 (0.50) | CSNK1A1CLK4PIN1LMNATSHR | |
| SCHEMBL4770177 | 0.72 | POLB (0.33) | IRAK1IRAK4TSHRNMT1ALDH1A1 | |
| SCHEMBL4773917 | 0.72 | ALDH1A1 (0.42) | CSNK1A1CLK4PIN1LMNATSHR | |
| SCHEMBL4765379 | 0.67 | CSNK1A1 (0.44) | CSNK1A1CLK4PIN1MAPK1KDM4E | |
| SCHEMBL24135156 | 0.67 | CSNK1A1 (0.60) | CSNK1A1CLK4PIN1KDM4EALDH1A1 | |
| SCHEMBL11048901 | 0.66 | KMT2A (0.47) | IRAK1IRAK4LMNATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |