Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28353905 | 0.76 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2KDM4EMAPTHPGD | |
| SCHEMBL4768927 | 0.74 | NFKB1 (0.37) | ALDH1A1SMN1; SMN2KDM4EMAPTHPGD | |
| SCHEMBL6826068 | 0.74 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KDM4EMAPTHPGD | |
| SCHEMBL4773830 | 0.73 | CSNK1A1 (0.43) | ALDH1A1CSNK1A1CLK4PIN1 | |
| SCHEMBL4765891 | 0.72 | CSNK1A1 (0.51) | ALDH1A1CSNK1A1CLK4KDM4EKMT2A | |
| SCHEMBL4773492 | 0.72 | CSNK1A1 (0.45) | ALDH1A1SMN1; SMN2CSNK1A1CLK4KDM4E | |
| SCHEMBL4764036 | 0.71 | CSNK1A1 (0.50) | ALDH1A1SMN1; SMN2CSNK1A1CLK4KDM4E | |
| SCHEMBL4769052 | 0.71 | CSNK1A1 (0.44) | CSNK1A1CLK4NFKB1PIN1 | |
| SCHEMBL4763570 | 0.71 | CSNK1A1 (0.44) | ALDH1A1CSNK1A1CLK4L3MBTL1PIN1 | |
| SCHEMBL22995037 | 0.71 | NFKB1 (0.37) | ALDH1A1SMN1; SMN2KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |