Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29314144 | 0.83 | ADORA2A (0.38) | CSNK1A1CLK4GBA1SLC9A5ROCK2 | |
| SCHEMBL4773492 | 0.83 | CSNK1A1 (0.45) | CSNK1A1CLK4PIN1GBA1AR | |
| SCHEMBL2530563 | 0.80 | SLC9A5 (0.36) | GBA1SLC9A5GRM4METALDH1A1 | |
| SCHEMBL4763570 | 0.76 | CSNK1A1 (0.44) | CSNK1A1CLK4PIN1ARALDH1A1 | |
| SCHEMBL4769052 | 0.76 | CSNK1A1 (0.44) | CSNK1A1CLK4PIN1AR | |
| SCHEMBL4765891 | 0.74 | CSNK1A1 (0.51) | CSNK1A1CLK4PIN1ALDH1A1 | |
| SCHEMBL5723859 | 0.74 | PIN1 (0.52) | CSNK1A1CLK4PIN1FGFR4SRC | |
| SCHEMBL4764036 | 0.73 | CSNK1A1 (0.50) | CSNK1A1CLK4PIN1ARALDH1A1 | |
| SCHEMBL4773917 | 0.73 | ALDH1A1 (0.42) | CSNK1A1CLK4PIN1ALDH1A1 | |
| SCHEMBL5723201 | 0.70 | PIN1 (0.49) | CSNK1A1CLK4PIN1FGFR4SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |