Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 9/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | ATF1 | P18846 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773492 | 0.78 | CSNK1A1 (0.45) | CSNK1A1CLK4ARPIN1 | |
| SCHEMBL4763570 | 0.77 | CSNK1A1 (0.44) | CSNK1A1CLK4ARPIN1 | |
| SCHEMBL4773830 | 0.76 | CSNK1A1 (0.43) | CSNK1A1CLK4ARPIN1 | |
| SCHEMBL4765891 | 0.75 | CSNK1A1 (0.51) | CSNK1A1CLK4PIN1 | |
| SCHEMBL4764036 | 0.74 | CSNK1A1 (0.50) | CSNK1A1CLK4ARPIN1 | |
| SCHEMBL4773917 | 0.71 | ALDH1A1 (0.42) | CSNK1A1CLK4PIN1NFKB1 | |
| SCHEMBL24135156 | 0.69 | CSNK1A1 (0.60) | CSNK1A1CLK4PIN1NFKB1 | |
| SCHEMBL4769009 | 0.69 | NFKB1 (0.40) | ATF1NFKB1 | |
| SCHEMBL4766382 | 0.68 | CSNK1A1 (0.46) | CSNK1A1CLK4ARPIN1 | |
| SCHEMBL29314407 | 0.66 | CDK1 (0.36) | ARNUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |