Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 10/20 | 0.59 |
| ▸ | EDNRA | P25101 | 10/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.57 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.57 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.46 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.46 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.46 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5889114 | 0.86 | TUBB4A (0.59) | EDNRBEDNRAPABPC1EIF4HTUBB4A | |
| SCHEMBL4937386 | 0.79 | PABPC1 (0.47) | EDNRBEDNRAPABPC1EIF4HTUBB4A | |
| SCHEMBL21465511 | 0.78 | MEN1 (0.67) | EDNRBEDNRAPABPC1EIF4HMEN1 | |
| SCHEMBL9537134 | 0.74 | KDM4E (0.58) | EDNRBEDNRAPABPC1EIF4HTUBB4A | |
| SCHEMBL7069090 | 0.72 | EDNRB (0.91) | EDNRBEDNRAMEN1KMT2AMAPT | |
| SCHEMBL6527378 | 0.71 | KMT2A (0.62) | PABPC1EIF4HMEN1KMT2AMAPT | |
| SCHEMBL5805176 | 0.70 | EDNRA (0.64) | EDNRBEDNRAPABPC1EIF4HTUBB4A | |
| SCHEMBL4762798 | 0.70 | TUBB4A (0.74) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16240662 | 0.68 | PTGDR2 (0.61) | MEN1KMT2AMAPTCYP3A4ALOX15 | |
| SCHEMBL21465505 | 0.67 | PABPC1 (0.57) | PABPC1EIF4HTUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287469-A1 | Phosphoinositide 3-Kinase Inhibitors for Inhibiting Leukocyte Accumulation | DIACOVO THOMAS G | 2008-11-20 | — | — | US | claimed |
| EP-1885356-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR INHIBITING LEUKOCYTE ACCUMULATION | ICOS CORPORATION (US) | 2008-02-13 | — | — | EP | claimed |
| WO-2006089106-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR INHIBITING LEUKOCYTE ACCUMULATION | ICOS CORPORATION (US) | 2006-08-24 | — | — | WO | claimed |
| US-7074814-B2 | 3-substituted indoles and derivatives thereof as therapeutic agents | WARNER-LAMBERT COMPANY LLC (US) | 2006-07-11 | — | — | US | claimed |
| EP-1644360-A1 | 3-SUBSTITUTED INDOLES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | Warner-Lambert Company LLC (US) | 2006-04-12 | — | — | EP | claimed |
| US-20050004195-A1 | 3-Substituted indoles and derivatives thereof as therapeutic agents | PARA KIMBERLY SUZANNE (US) | 2005-01-06 | — | — | US | claimed |
| WO-2004108708-A1 | 3-SUBSTITUTED INDOLES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-12-16 | — | — | WO | claimed |
| US-20080287469-A1 | Phosphoinositide 3-Kinase Inhibitors for Inhibiting Leukocyte Accumulation | DIACOVO THOMAS G | 2008-11-20 | — | — | US | disclosed |
| EP-1885356-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR INHIBITING LEUKOCYTE ACCUMULATION | ICOS CORPORATION (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006089106-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR INHIBITING LEUKOCYTE ACCUMULATION | ICOS CORPORATION (US) | 2006-08-24 | — | — | WO | disclosed |
| US-7074814-B2 | 3-substituted indoles and derivatives thereof as therapeutic agents | WARNER-LAMBERT COMPANY LLC (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1644360-A1 | 3-SUBSTITUTED INDOLES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | Warner-Lambert Company LLC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-20050004195-A1 | 3-Substituted indoles and derivatives thereof as therapeutic agents | PARA KIMBERLY SUZANNE (US) | 2005-01-06 | — | — | US | disclosed |
| WO-2004108708-A1 | 3-SUBSTITUTED INDOLES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004195-A1 | 3-Substituted indoles and derivatives thereof as therapeutic agents | IDO1, TPH1, IDO2 | EDNRB 500/4885EDNRA 157/4885PABPC1 2852/4885 |
| US-20080287469-A1 | Phosphoinositide 3-Kinase Inhibitors for Inhibiting Leukocyte Accumulation | PI4KB, PIK3CA, PI4KA | EDNRB 1628/4885EDNRA 1595/4885PABPC1 2102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.