Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.54 |
| ▸ | PTAFR | P25105 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | GALR3 | O60755 | 2/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790952 | 0.89 | HRH3 (0.42) | HRH3PTAFRHDAC1HDAC6GALR3 | |
| SCHEMBL4761940 | 0.89 | HRH3 (0.42) | HRH3PTAFRHDAC1HDAC6GALR3 | |
| SCHEMBL4792764 | 0.88 | ADAM17 (0.46) | HRH3PTAFRCYP2D6HRH1 | |
| SCHEMBL4161023 | 0.85 | HRH3 (0.52) | HRH3KCNH2 | |
| SCHEMBL4889725 | 0.84 | KCNH2 (0.42) | HRH3PTAFRHDAC1KCNH2 | |
| SCHEMBL4793576 | 0.83 | MEN1 (0.40) | KCNH2 | |
| SCHEMBL4791508 | 0.82 | LMNA (0.42) | HRH3PTAFRKCNH2 | |
| SCHEMBL4764354 | 0.81 | POLB (0.41) | — | |
| SCHEMBL4790935 | 0.81 | DRD2 (0.42) | HRH3RAB9AKCNH2 | |
| SCHEMBL2879390 | 0.80 | RECQL (0.42) | HRH3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |