Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | SMURF1 | Q9HCE7 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765386 | 0.96 | TP53 (0.55) | TP53SMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL4772218 | 0.89 | SLC2A1 (0.42) | TP53SMN1; SMN2SLC2A1GAAHTT | |
| Trifluoroacetic Acid SCHEMBL4774586 | 0.86 | MAPT (0.51) | SMN1; SMN2SLC2A1ALDH1A1LMNAMET | |
| Trifluoroacetic Acid SCHEMBL4765302 | 0.85 | AXL (0.42) | TP53SMN1; SMN2SLC2A1L3MBTL1GAA | |
| Trifluoroacetic Acid SCHEMBL4768481 | 0.85 | NPY5R (0.49) | SLC2A1HRH3 | |
| Trifluoroacetic Acid SCHEMBL4775487 | 0.85 | KMT2A (0.53) | SLC2A1ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL4771101 | 0.84 | HRH3 (0.44) | TP53SMN1; SMN2GAAHTTROCK1 | |
| Trifluoroacetic Acid SCHEMBL4771967 | 0.84 | SLC2A1 (0.45) | TP53SMN1; SMN2SLC2A1KDM4EGAA | |
| Trifluoroacetic Acid SCHEMBL4771045 | 0.83 | RAB9A (0.53) | SMN1; SMN2SLC2A1KMT2AMEN1ROCK1 | |
| Trifluoroacetic Acid SCHEMBL4765180 | 0.82 | POLB (0.52) | TP53SMN1; SMN2SLC2A1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | US | claimed |
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | HRH3, HRH4, HRH1 | TP53 4863/4885SMN1; SMN2 2487/4885SLC2A1 4665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.