Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683489 | 0.86 | TGFBR1 (0.59) | TGFBR1PDE10AMAPK14 | |
| SCHEMBL3247895 | 0.77 | TGFBR1 (0.68) | TGFBR1MAPK14NPC1CSNK1DBRD4 | |
| SCHEMBL11992044 | 0.75 | TGFBR1 (0.60) | TGFBR1KDM4ENPC1METAP1 | |
| SCHEMBL27907019 | 0.73 | MAPK14 (0.56) | TGFBR1PDE10AMAPK14CSNK1DCSNK1E | |
| SCHEMBL373397 | 0.73 | TGFBR1 (0.56) | TGFBR1MAPK14KDM4ENPC1METAP1 | |
| SCHEMBL8489264 | 0.71 | CSNK1D (0.61) | TGFBR1MAPK14CSNK1DCSNK1E | |
| SCHEMBL13874006 | 0.69 | KDM4E (0.43) | KDM4ENPC1METAP1BRD4 | |
| SCHEMBL25818831 | 0.69 | KDM4E (0.43) | KDM4ENPC1METAP1BRD4 | |
| SCHEMBL29663058 | 0.69 | ALDH1A1 (0.54) | TGFBR1KDM4ENPC1 | |
| SCHEMBL5526916 | 0.69 | MAP4K4 (0.51) | TGFBR1PDE10AMAPK14NPC1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122212-A1 | TGF-BETA PATHWAY INHIBITORS FOR ENHANCEMENT OF CELLULAR REPROGRAMMING OF HUMAN CELLS | IPIERIAN, INC. | 2012-05-17 | — | — | US | disclosed |