Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.60 |
| ▸ | LMNA | P02545 | 6/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.60 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 1/20 | 0.49 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9743791 | 0.84 | DRD3 (0.45) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9743778 | 0.84 | DRD3 (0.45) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL30539983 | 0.83 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL6790985 | 0.81 | ALDH1A1 (0.61) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| Potassium SCHEMBL9744154 | 0.81 | HSD17B10 (0.45) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9744143 | 0.81 | HSD17B10 (0.45) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL6248075 | 0.80 | KDM4E (0.60) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9344507 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL6806695 | 0.80 | LMNA (0.53) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL6223889 | 0.79 | ALDH1A1 (0.59) | ALDH1A1KDM4ELMNAHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309565-B1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2008-04-09 | — | — | EP | disclosed |
| US-6878704-B2 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-04-12 | — | — | US | disclosed |
| US-20040058937-A1 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-25 | — | — | US | disclosed |
| EP-1309565-A1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2003010144-A2 | A PROCESS FOR SYNTHESIS OF FLUOROQUINOLONIC DERIVATIVES | FARMACEUTSKO-HEMIJSKA INDUSTRIJA 'ZDRAVLJE' (YU) | 2003-02-06 | — | — | WO | disclosed |
| WO-2002012199-A1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-14 | — | — | WO | disclosed |
| EP-0049593-B1 | 1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-3-QUINOLINE CARBOXYLIC ACID AND METAL SALTS THEREOF USEFUL IN BURN THERAPY | Fox, Charles l., Jr. (US) | 1986-08-27 | — | — | EP | disclosed |
| US-4522819-A | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof useful in burn therapy | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1985-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058937-A1 | Heterocyclic mutilin esters and their use as antibacterials | MLN, MSH2, MRPL21 | ALDH1A1 852/4885KDM4E 4142/4885LMNA 2120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.