Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DHPS | P49366 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347159 | 0.78 | ALDH1A1 (0.49) | HPGDNPSR1ALDH1A1HSD17B10KDM4E | |
| SCHEMBL8345655 | 0.76 | MAPT (0.42) | HPGDALDH1A1HSD17B10KDM4ERXFP1 | |
| SCHEMBL4774542 | 0.71 | HTT (0.44) | HPGDALDH1A1HSD17B10KDM4ERXFP1 | |
| SCHEMBL5256030 | 0.70 | DHPS (0.47) | MAPK1MEN1KMT2ASMN1; SMN2DHPS | |
| SCHEMBL937501 | 0.70 | CYP2D6 (0.70) | HPGDALDH1A1HSD17B10KDM4EMAPK1 | |
| SCHEMBL1084188 | 0.69 | CYP1A2 (0.50) | HPGDALDH1A1HSD17B10KDM4EMAPK1 | |
| SCHEMBL1084031 | 0.69 | CYP1A2 (0.50) | HPGDALDH1A1HSD17B10KDM4EMAPK1 | |
| SCHEMBL6255073 | 0.68 | ADORA2A (0.49) | HPGDNPSR1ALDH1A1HSD17B10KDM4E | |
| SCHEMBL12929774 | 0.66 | PTPN11 (0.38) | MAPTGBA1 | |
| SCHEMBL1083894 | 0.66 | CYP2D6 (0.56) | HPGDALDH1A1HSD17B10KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549316-A4 | INHIBITORS OF TFGbeta | SCIOS INC (US) | 2008-04-09 | — | — | EP | disclosed |
| EP-1549316-A1 | INHIBITORS OF TFG&bgr; | SCIOS INC. (US) | 2005-07-06 | — | — | EP | disclosed |
| US-20040132730-A1 | Inhibitors of TGFbeta | SCIOS, INC. | 2004-07-08 | — | — | US | disclosed |
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132730-A1 | Inhibitors of TGFbeta | TGFBR1, TGFBR2, TGFB1 | HPGD 1323/4885NPSR1 3089/4885ALDH1A1 2530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.