Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4830592 | 0.81 | KCNA3 (0.36) | KCNA3SLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL14294296 | 0.78 | OPRM1 (0.37) | KCNA3SLC6A4SLC6A2HCAR3HCAR2 | |
| SCHEMBL735724 | 0.75 | MEN1 (0.57) | KCNA3MEN1CYP2C9KMT2AOPRM1 | |
| SCHEMBL517934 | 0.75 | KCNA3 (0.40) | KCNA3MEN1CYP2C9KMT2ASLC6A4 | |
| SCHEMBL4765099 | 0.74 | SLC6A4 (0.36) | KCNA3SLC6A4SLC6A2SLC6A3OPRM1 | |
| Hydrochloric Acid SCHEMBL11093542 | 0.74 | MEN1 (0.55) | KCNA3MEN1CYP2C9KMT2AOPRM1 | |
| SCHEMBL11097091 | 0.74 | SLC6A4 (0.39) | MEN1CYP2C9KMT2ASLC6A4SLC6A3 | |
| SCHEMBL11092884 | 0.72 | SLC6A4 (0.40) | MEN1CYP2C9KMT2ASLC6A4SLC6A2 | |
| SCHEMBL11091107 | 0.72 | HSD11B1 (0.41) | MEN1CYP2C9KMT2ASLC6A4SLC6A3 | |
| SCHEMBL11067006 | 0.72 | SLC6A4 (0.44) | MEN1CYP2C9KMT2ASLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725567-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH AFFINITY TO THE ORL-1 RECEPTOR | GRUENENTHAL GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1725567-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH AFFINITY TO THE ORL-1 RECEPTOR | GRUENENTHAL GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| US-7332519-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2008-02-19 | — | — | US | disclosed |
| US-7332519-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2008-02-19 | — | — | US | disclosed |
| EP-1725567-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH AFFINITY TO THE ORL-1 RECEPTOR | Grünenthal GmbH (DE) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005066183-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH AFFINITY FOR THE ORL1-RECEPTOR | Grünenthal GmbH (DE) | 2005-07-21 | — | — | WO | disclosed |