Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14294296 | 0.82 | OPRM1 (0.37) | KCNA3OPRM1OPRL1OPRK1SLC6A4 | |
| SCHEMBL4767361 | 0.81 | KCNA3 (0.42) | KCNA3OPRM1OPRL1OPRK1SLC6A4 | |
| SCHEMBL4765099 | 0.78 | SLC6A4 (0.36) | KCNA3OPRM1OPRL1OPRK1SLC6A4 | |
| SCHEMBL20217389 | 0.75 | KCNA3 (0.35) | KCNA3SLC6A9SLC6A4SLC6A2KIF11 | |
| SCHEMBL30295320 | 0.74 | ESR1 (0.45) | KCNA3SLC6A9CHRM1 | |
| SCHEMBL9557318 | 0.72 | KCNA3 (0.36) | KCNA3SLC6A9SLC6A4SLC6A2KIF11 | |
| SCHEMBL294762 | 0.72 | OPRM1 (0.61) | OPRM1OPRL1OPRK1SLC6A4 | |
| SCHEMBL24462848 | 0.71 | GRIN1 (0.49) | KCNA3OPRM1OPRK1SLC6A9SLC6A4 | |
| SCHEMBL18769615 | 0.71 | KCNA3 (0.30) | KCNA3 | |
| SCHEMBL23595678 | 0.71 | GRIN1 (0.49) | KCNA3OPRM1OPRK1SLC6A9SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332519-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2008-02-19 | — | — | US | disclosed |
| US-20050192333-A1 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192333-A1 | Spirocyclic cyclohexane compounds | OPRL1, OPRK1, OPRD1 | KCNA3 1777/4885OPRM1 5/4885OPRL1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.