Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14294296 | 0.79 | OPRM1 (0.37) | SLC6A4OPRM1OPRL1OPRK1KIF11 | |
| SCHEMBL4830592 | 0.78 | KCNA3 (0.36) | SLC6A4SLC6A3OPRM1OPRL1OPRK1 | |
| SCHEMBL734156 | 0.77 | OPRM1 (0.57) | SLC6A4SLC6A3OPRM1OPRL1OPRK1 | |
| SCHEMBL517588 | 0.76 | OPRM1 (0.39) | SLC6A4SLC6A3OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL9897862 | 0.76 | OPRM1 (0.56) | SLC6A4SLC6A3OPRM1OPRL1OPRK1 | |
| SCHEMBL4767361 | 0.74 | KCNA3 (0.42) | SLC6A4SLC6A3OPRM1OPRL1OPRK1 | |
| SCHEMBL4762122 | 0.73 | OPRM1 (0.30) | OPRM1 | |
| SCHEMBL3927005 | 0.72 | OPRM1 (0.49) | SLC6A4SLC6A3OPRM1OPRL1ALDH1A1 | |
| SCHEMBL26627224 | 0.72 | MAOA (0.41) | SLC6A4SLC6A3KCNA3SLC6A2 | |
| SCHEMBL4768434 | 0.71 | AKR1C1 (0.38) | KCNA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725567-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH AFFINITY TO THE ORL-1 RECEPTOR | GRUENENTHAL GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| US-7332519-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2008-02-19 | — | — | US | disclosed |
| EP-1725567-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH AFFINITY TO THE ORL-1 RECEPTOR | Grünenthal GmbH (DE) | 2006-11-29 | — | — | EP | disclosed |
| US-20050192333-A1 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2005-09-01 | — | — | US | disclosed |
| WO-2005066183-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES WITH AFFINITY FOR THE ORL1-RECEPTOR | Grünenthal GmbH (DE) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192333-A1 | Spirocyclic cyclohexane compounds | OPRL1, OPRK1, OPRD1 | SLC6A4 1987/4885SLC6A3 1585/4885OPRM1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.