Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763006 | 0.89 | NPC1 (0.36) | — | |
| SCHEMBL6588766 | 0.87 | CTSK (0.32) | CTSLCTSBCTSS | |
| SCHEMBL6590220 | 0.86 | RAB9A (0.38) | — | |
| SCHEMBL4766746 | 0.84 | CAPN1 (0.34) | MMP2MMP13 | |
| SCHEMBL4763320 | 0.81 | CTSL (0.37) | CTSLCTSBCTSS | |
| SCHEMBL7422805 | 0.80 | POLB (0.35) | — | |
| SCHEMBL4767192 | 0.79 | TAS1R3 (0.44) | — | |
| SCHEMBL4764901 | 0.78 | MAPT (0.43) | — | |
| SCHEMBL4764900 | 0.78 | MAPT (0.43) | — | |
| SCHEMBL4768775 | 0.78 | GRN (0.45) | CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |