Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PLK1 | P53350 | 3/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.42 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772259 | 0.86 | KMT2A (0.42) | CHEK1KMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL4768085 | 0.85 | SRC (0.49) | PLK1PLK3PLK2CA2CA9 | |
| SCHEMBL4769260 | 0.84 | CA2 (0.48) | CHEK1CA1CA2CA9AURKA | |
| SCHEMBL4770543 | 0.83 | CA2 (0.42) | CHEK1KMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL4772257 | 0.83 | CA2 (0.41) | CHEK1CA1CA2CA9AURKA | |
| SCHEMBL6221016 | 0.83 | NPC1 (0.53) | CA2CA9MAPTCDK2CCNT1 | |
| SCHEMBL4763724 | 0.83 | CA2 (0.47) | CHEK1CA1CA2CA9AURKA | |
| SCHEMBL4770616 | 0.83 | RAB9A (0.48) | KMT2AALDH1A1HPGDMEN1PLK1 | |
| SCHEMBL4763965 | 0.82 | CHEK1 (0.41) | CHEK1KMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL4763831 | 0.81 | ALDH1A1 (0.52) | KMT2AALDH1A1HPGDMEN1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |