Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.41 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774410 | 0.93 | RAB9A (0.52) | RAB9APTK2PTK2BALDH1A1HPGD | |
| SCHEMBL6226667 | 0.83 | RAB9A (0.52) | RAB9APTK2PTK2BATMNPC1 | |
| SCHEMBL4772259 | 0.83 | KMT2A (0.42) | ALDH1A1HPGDKDM4EMAPTCASP1 | |
| SCHEMBL4768575 | 0.83 | CHEK1 (0.46) | ALDH1A1HPGDKDM4EMAPTCASP1 | |
| SCHEMBL4769260 | 0.81 | CA2 (0.48) | PTK2AURKACA1CA2CA9 | |
| SCHEMBL4768085 | 0.81 | SRC (0.49) | MERTKCA2CA9PLK1PLK3 | |
| SCHEMBL4763831 | 0.80 | ALDH1A1 (0.52) | ALDH1A1HPGDKDM4ECASP1CASP7 | |
| SCHEMBL4763724 | 0.80 | CA2 (0.47) | RAB9AAURKANPC1CA1CA2 | |
| SCHEMBL4768143 | 0.79 | SYK (0.53) | AURKACA2CA9PLK1PLK3 | |
| SCHEMBL4770543 | 0.79 | CA2 (0.42) | ALDH1A1HPGDKDM4EMAPTCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |