Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATF1 | P18846 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20980101 | 0.84 | L3MBTL1 (0.50) | L3MBTL1KDM4EHTTALDH1A1HSD17B10 | |
| SCHEMBL4774497 | 0.84 | NFKB1 (0.40) | ALDH1A1TSHRATF1NFKB1SYK | |
| SCHEMBL4769101 | 0.80 | STK17B (0.43) | ALDH1A1LMNAATF1NFKB1SYK | |
| SCHEMBL2842558 | 0.80 | L3MBTL1 (0.53) | L3MBTL1KDM4EHTTALDH1A1LMNA | |
| SCHEMBL4765257 | 0.80 | STK17B (0.47) | L3MBTL1KDM4ENFKB1STK17BSTK17A | |
| SCHEMBL4768852 | 0.80 | ALDH1A1 (0.46) | ALDH1A1ATF1NFKB1SYKSTK17B | |
| SCHEMBL4769948 | 0.80 | STK17B (0.46) | L3MBTL1KDM4EHTTALDH1A1LMNA | |
| SCHEMBL4772853 | 0.78 | TRPA1 (0.41) | ATF1NFKB1SYKSTK17BSTK17A | |
| SCHEMBL4772216 | 0.78 | STK17B (0.40) | HTTALDH1A1TSHRATF1NFKB1 | |
| SCHEMBL4765932 | 0.78 | STK17B (0.43) | ALDH1A1TSHRATF1NFKB1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |