Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765378 | 0.84 | ADRA2C (0.41) | ADRA2CQDPRKCNH2HRH3HTR1D | |
| SCHEMBL28772336 | 0.81 | LMNA (0.40) | SLC18A3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27928432 | 0.80 | SLC18A3 (0.43) | SLC18A3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL158531 | 0.78 | QDPR (0.55) | SLC18A3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4768850 | 0.76 | SLC18A3 (0.40) | SLC18A3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15651723 | 0.75 | SLC18A3 (0.40) | SLC18A3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28776171 | 0.74 | SLC18A3 (0.39) | SLC18A3ESRRGLSSKCNH2HRH3 | |
| SCHEMBL1475617 | 0.74 | ESRRG (0.55) | SLC18A3ALDH1A1ESRRGKDM1AKCNH2 | |
| SCHEMBL15652128 | 0.73 | ESRRG (0.38) | SLC18A3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28772334 | 0.73 | ALDH1A1 (0.42) | SLC18A3HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937681-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007033232-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |