Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 11/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4765400 | 0.95 | AURKA (0.52) | AURKATP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4773081 | 0.90 | AURKA (0.56) | AURKATP53MEN1KMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4771910 | 0.86 | AURKA (0.52) | AURKATP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4767370 | 0.81 | MEN1 (0.58) | TP53MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL4765359 | 0.80 | NPC1 (0.44) | TP53MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL4765481 | 0.80 | HRH3 (0.44) | TP53MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4772031 | 0.79 | NPC1 (0.43) | TP53MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL4768623 | 0.78 | RAB9A (0.58) | TP53SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL4774462 | 0.77 | RAB9A (0.59) | MEN1KMT2ASMN1; SMN2HPGDPOLB | |
| SCHEMBL4772484 | 0.77 | NPC1 (0.55) | TP53SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |