Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4771910 | 0.96 | AURKA (0.52) | AURKATP53LMNAMAPTMEN1 | |
| SCHEMBL4771087 | 0.90 | AURKA (0.58) | AURKATP53LMNAMAPTMEN1 | |
| Trifluoroacetic Acid SCHEMBL4765400 | 0.86 | AURKA (0.52) | AURKATP53LMNAMAPTMEN1 | |
| SCHEMBL4773028 | 0.78 | RAB9A (0.60) | TP53LMNAMAPTMEN1KMT2A | |
| SCHEMBL22095109 | 0.77 | LMNA (0.67) | AURKATP53LMNAMAPTMEN1 | |
| SCHEMBL4768212 | 0.75 | NPC1 (0.58) | TP53MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4771157 | 0.75 | KMT2A (0.56) | TP53LMNAMAPTMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL4770822 | 0.75 | RAB9A (0.53) | TP53LMNAMAPTMEN1KMT2A | |
| SCHEMBL4767370 | 0.74 | MEN1 (0.58) | TP53LMNAMAPTMEN1KMT2A | |
| SCHEMBL23928545 | 0.74 | AURKA (0.76) | AURKATP53LMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |