Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 6/20 | 0.42 |
| ▸ | MERTK | Q12866 | 6/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 6/20 | 0.41 |
| ▸ | CA1 | P00915 | 6/20 | 0.41 |
| ▸ | CA2 | P00918 | 6/20 | 0.41 |
| ▸ | CA3 | P07451 | 6/20 | 0.41 |
| ▸ | CA6 | P23280 | 6/20 | 0.41 |
| ▸ | CA5A | P35218 | 6/20 | 0.41 |
| ▸ | CA7 | P43166 | 6/20 | 0.41 |
| ▸ | CA9 | Q16790 | 6/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.41 |
| ▸ | CA4 | P22748 | 4/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 5/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487618 | 0.83 | JAK2 (0.38) | JAK2 | |
| SCHEMBL28526131 | 0.69 | OPRK1 (0.35) | TSHR | |
| SCHEMBL28909314 | 0.69 | OPRK1 (0.38) | JAK2 | |
| SCHEMBL28526521 | 0.69 | ALDH1A1 (0.34) | TSHRJAK2 | |
| SCHEMBL28534400 | 0.68 | GAA (0.35) | HPGDTSHRJAK2 | |
| SCHEMBL3546872 | 0.65 | TRPV1 (0.32) | TSHR | |
| SCHEMBL13733958 | 0.65 | JAK2 (0.47) | JAK2 | |
| SCHEMBL22145328 | 0.65 | LCK (0.42) | — | |
| SCHEMBL10536742 | 0.64 | NAAA (0.50) | — | |
| SCHEMBL7489466 | 0.64 | NFKB1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |