Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | ITK | Q08881 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777334 | 0.82 | SCN3A (0.46) | MEN1KMT2AALDH1A1NAMPTCSF1R | |
| SCHEMBL4777423 | 0.80 | MEN1 (0.41) | MEN1KMT2AKDM4EALDH1A1TRPV1 | |
| SCHEMBL4776425 | 0.75 | TDP1 (0.42) | MEN1KMT2AALDH1A1NAMPTITK | |
| SCHEMBL4773435 | 0.74 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1TRPV1HSD17B10 | |
| SCHEMBL31236179 | 0.73 | TRPV1 (0.51) | TRPV1NAMPTITKSLC40A1CSF1R | |
| SCHEMBL4776574 | 0.70 | P2RX7 (0.42) | TRPV1NAMPTP2RX7 | |
| SCHEMBL4773151 | 0.69 | MAPT (0.44) | MEN1KMT2AALDH1A1NAMPTITK | |
| SCHEMBL4777412 | 0.69 | EPHX2 (0.46) | ALDH1A1NAMPTNPC1RAB9A | |
| SCHEMBL4881694 | 0.69 | DGAT2 (0.40) | KMT2ATRPV1ITKP2RX7 | |
| SCHEMBL4768151 | 0.69 | MAPT (0.49) | MEN1KMT2AALDH1A1TRPV1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |