Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777340 | 0.83 | GAA (0.52) | GAA | |
| SCHEMBL4776427 | 0.77 | GAA (0.54) | ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL4773432 | 0.74 | MEN1 (0.46) | ALDH1A1KMT2AHSD17B10MEN1NAMPT | |
| SCHEMBL4773154 | 0.72 | GAA (0.55) | KMT2AMEN1GAA | |
| SCHEMBL4881694 | 0.71 | DGAT2 (0.40) | HTTKMT2AP2RX7NR1H2TRPV1 | |
| SCHEMBL4768157 | 0.71 | GAA (0.70) | ALDH1A1NAMPTGAA | |
| SCHEMBL4776579 | 0.71 | GAA (0.42) | HTTP2RX7GAA | |
| SCHEMBL31236179 | 0.70 | TRPV1 (0.51) | NAMPTADORA2ATRPV1 | |
| SCHEMBL4773433 | 0.70 | KCNH2 (0.40) | NR1H2 | |
| SCHEMBL27823398 | 0.70 | ITK (0.45) | P2RX7NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |