Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 3/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MTTP | P55157 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773435 | 0.71 | ALDH1A1 (0.48) | NR1H2TRPV1HTTKMT2AP2RX7 | |
| SCHEMBL27823398 | 0.71 | ITK (0.45) | ITKNR1H2P2RX7 | |
| SCHEMBL4776427 | 0.71 | GAA (0.54) | KMT2A | |
| SCHEMBL4793709 | 0.70 | DGAT2 (0.39) | DGAT2ITKTRPV1HTTKMT2A | |
| SCHEMBL30810190 | 0.70 | BCAT2 (0.53) | ALOX5APFEN1 | |
| Hydrochloric Acid SCHEMBL30810233 | 0.69 | BCAT2 (0.51) | ALOX5APFEN1 | |
| SCHEMBL4773432 | 0.69 | MEN1 (0.46) | ITKTRPV1KMT2AP2RX7 | |
| SCHEMBL4776425 | 0.68 | TDP1 (0.42) | DGAT2ITKKMT2A | |
| SCHEMBL1495701 | 0.68 | PTGS2 (0.51) | ITK | |
| SCHEMBL27823396 | 0.67 | ITK (0.44) | DGAT2ITKTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |