Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 11/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773435 | 0.70 | ALDH1A1 (0.48) | NR1H2 | |
| SCHEMBL4777340 | 0.67 | GAA (0.52) | — | |
| SCHEMBL30394818 | 0.66 | MAOB (0.46) | MRGPRX4 | |
| SCHEMBL2310832 | 0.66 | MAOB (0.46) | MRGPRX4 | |
| SCHEMBL27654168 | 0.64 | DAO (0.48) | MRGPRX4 | |
| SCHEMBL25376011 | 0.63 | TRPM8 (0.41) | KCNH2TRPM8 | |
| SCHEMBL30481945 | 0.63 | TRPM8 (0.41) | KCNH2TRPM8 | |
| SCHEMBL17092298 | 0.63 | KCNH2 (0.45) | KCNH2TRPM8MRGPRX4 | |
| SCHEMBL4853179 | 0.62 | PLAAT3 (0.47) | MRGPRX4 | |
| SCHEMBL18256345 | 0.61 | GRB2 (0.54) | MRGPRX4PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |