Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17092136 | 0.82 | VNN1 (0.47) | MEN1KMT2AMLYCDHDAC6HDAC3 | |
| SCHEMBL14540447 | 0.77 | KCNH2 (0.45) | KCNH2MLYCDPPARDTACR1MRGPRX4 | |
| SCHEMBL17092309 | 0.76 | P2RX7 (0.38) | KCNH2MEN1KMT2AMLYCDHDAC6 | |
| SCHEMBL17092406 | 0.75 | TACR1 (0.38) | MEN1KMT2AHDAC6HDAC3HDAC4 | |
| SCHEMBL17092327 | 0.72 | TACR1 (0.40) | KCNH2MEN1KMT2AHDAC6HDAC1 | |
| SCHEMBL24468909 | 0.71 | KCNH2 (0.38) | KCNH2MEN1KMT2AHDAC6HDAC3 | |
| SCHEMBL15645684 | 0.70 | HSD17B2 (0.56) | MEN1KMT2A | |
| SCHEMBL17091853 | 0.70 | LOXL2 (0.43) | MEN1KMT2AMLYCDHDAC6HDAC3 | |
| SCHEMBL21491797 | 0.70 | PPARD (0.43) | KCNH2MEN1KMT2AHDAC6HDAC3 | |
| SCHEMBL14641817 | 0.69 | TRPV4 (0.42) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035790-B2 | RORγ modulators | EXELIXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20150266856-A1 | RORGamma Modulators | EXELIXIS, INC. | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266856-A1 | RORGamma Modulators | RORB, RORA, RORC | KCNH2 2016/4885MEN1 2686/4885KMT2A 2212/4885 |
| US-10035790-B2 | RORγ modulators | RORB, RORA, RORC | KCNH2 1711/4885MEN1 3362/4885KMT2A 2258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.