Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PTPRC | P08575 | 1/20 | 0.30 |
| ▸ | PTPRG | P23470 | 1/20 | 0.30 |
| ▸ | CPA1 | P15085 | 1/20 | 0.30 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766678 | 0.85 | ALDH1A1 (0.34) | KMT2AMEN1HPGDNPC1SMN1; SMN2 | |
| SCHEMBL4767519 | 0.83 | P4HTM (0.42) | KMT2AMEN1P4HTMHDAC8PPARG | |
| SCHEMBL4768134 | 0.78 | P4HTM (0.35) | P4HTMCPB2SMN1; SMN2 | |
| SCHEMBL4768165 | 0.78 | CTSA (0.38) | P4HTMPPARGPPARACPB2SMN1; SMN2 | |
| SCHEMBL4773852 | 0.78 | PPARG (0.41) | P4HTMPPARGPPARASMN1; SMN2 | |
| SCHEMBL4765186 | 0.76 | CCKAR (0.43) | KMT2AFABP4FABP5SMN1; SMN2 | |
| SCHEMBL4764854 | 0.74 | CCKAR (0.45) | — | |
| SCHEMBL4775316 | 0.73 | JAK2 (0.46) | — | |
| SCHEMBL4767426 | 0.73 | KMT2A (0.41) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4769975 | 0.72 | ATF1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | claimed |