Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 7/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767519 | 0.88 | P4HTM (0.42) | PPARGPPARAP4HTMSMN1; SMN2 | |
| SCHEMBL4768134 | 0.86 | P4HTM (0.35) | P4HTMSMN1; SMN2LMNAGRM8GRM4 | |
| SCHEMBL4771777 | 0.85 | MME (0.42) | PPARGPPARASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL4773748 | 0.78 | KMT2A (0.35) | PPARGPPARAP4HTMSMN1; SMN2 | |
| SCHEMBL4764854 | 0.77 | CCKAR (0.45) | L3MBTL1 | |
| SCHEMBL4768165 | 0.75 | CTSA (0.38) | PPARGPPARAP4HTMSMN1; SMN2 | |
| SCHEMBL4767426 | 0.75 | KMT2A (0.41) | SMN1; SMN2LMNAL3MBTL1KDM4E | |
| SCHEMBL4769975 | 0.74 | ATF1 (0.39) | KDM4E | |
| SCHEMBL4770006 | 0.74 | NFKB1 (0.47) | — | |
| SCHEMBL4775298 | 0.74 | ACHE (0.41) | PPARGPPARASMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | claimed |