Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 7/20 | 0.46 |
| ▸ | UBE2N | P61088 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706297 | 0.94 | ALDH1A1 (0.52) | SIGMAR1ALDH1A1CNR2UBE2NTDP1 | |
| SCHEMBL4781123 | 0.85 | CNR2 (0.48) | SIGMAR1ALDH1A1CNR2TDP1 | |
| SCHEMBL4708685 | 0.85 | HTR6 (0.43) | ALDH1A1LMNAMAPTPOLBKMT2A | |
| SCHEMBL4776252 | 0.83 | PTGDR2 (0.44) | SIGMAR1ALDH1A1CNR2MAPTPOLB | |
| Hydrochloric Acid SCHEMBL4774092 | 0.82 | LMNA (0.42) | SIGMAR1ALDH1A1CNR2TDP1LMNA | |
| SCHEMBL4774108 | 0.81 | KDM4E (0.44) | SIGMAR1ALDH1A1TDP1POLBMEN1 | |
| SCHEMBL4708182 | 0.81 | HTR6 (0.48) | ALDH1A1CNR2MAPTPOLBSMN1; SMN2 | |
| SCHEMBL4773925 | 0.79 | POLB (0.42) | ALDH1A1TDP1LMNAMAPTPOLB | |
| SCHEMBL4774098 | 0.79 | PTGDR2 (0.41) | LMNAMAPTMAPK1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4505995 | 0.79 | UBE2N (0.45) | SIGMAR1ALDH1A1UBE2NTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008000818-A1 | FLUORINATED INDOLEAMIDES USEFUL AS LIGANDS OF THE ORL-1 RECEPTOR | BRANE DISCOVERY S.R.L. (IT) | 2008-01-03 | — | — | WO | claimed |
| WO-2008000818-A1 | FLUORINATED INDOLEAMIDES USEFUL AS LIGANDS OF THE ORL-1 RECEPTOR | BRANE DISCOVERY S.R.L. (IT) | 2008-01-03 | — | — | WO | disclosed |