Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | USP14 | P54578 | 2/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778231 | 0.93 | KDM4E (0.46) | PTGDR2KDM4ESMN1; SMN2POLBTSHR | |
| SCHEMBL4781548 | 0.86 | LMNA (0.44) | PTGDR2KDM4ESMN1; SMN2POLBTSHR | |
| SCHEMBL4708685 | 0.85 | HTR6 (0.43) | PTGDR2KDM4ESMN1; SMN2POLBTSHR | |
| SCHEMBL4779231 | 0.85 | CNR2 (0.46) | PTGDR2KDM4EPOLBCNR1CNR2 | |
| SCHEMBL4779433 | 0.84 | PTGDR2 (0.50) | PTGDR2KDM4ESMN1; SMN2POLBTSHR | |
| SCHEMBL4708952 | 0.83 | CNR2 (0.41) | KDM4EPOLBCNR1CNR2ALDH1A1 | |
| SCHEMBL4774376 | 0.83 | SIGMAR1 (0.47) | SMN1; SMN2POLBCNR2ALDH1A1MAPT | |
| SCHEMBL4778810 | 0.82 | KDM4E (0.46) | PTGDR2KDM4ESMN1; SMN2POLBTSHR | |
| SCHEMBL4774108 | 0.82 | KDM4E (0.44) | PTGDR2KDM4ESMN1; SMN2POLBTSHR | |
| SCHEMBL4776203 | 0.82 | KDM4E (0.46) | PTGDR2KDM4ESMN1; SMN2POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008000818-A1 | FLUORINATED INDOLEAMIDES USEFUL AS LIGANDS OF THE ORL-1 RECEPTOR | BRANE DISCOVERY S.R.L. (IT) | 2008-01-03 | — | — | WO | claimed |
| WO-2008000818-A1 | FLUORINATED INDOLEAMIDES USEFUL AS LIGANDS OF THE ORL-1 RECEPTOR | BRANE DISCOVERY S.R.L. (IT) | 2008-01-03 | — | — | WO | disclosed |