Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | F7 | P08709 | 2/20 | 0.39 |
| ▸ | F3 | P13726 | 2/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14302669 | 0.89 | BRAF (0.47) | HRH4BRAFALDH1A1BLML3MBTL1 | |
| SCHEMBL4778366 | 0.83 | HRH4 (0.57) | HRH4ESR1ALDH1A1BLML3MBTL1 | |
| SCHEMBL14303425 | 0.79 | ABCG2 (0.45) | HRH4BRAFESR1ALDH1A1BLM | |
| SCHEMBL4774577 | 0.77 | CNR2 (0.51) | HRH4ESR1ALDH1A1BLML3MBTL1 | |
| SCHEMBL4795559 | 0.76 | SMN1; SMN2 (0.42) | ALDH1A1L3MBTL1 | |
| SCHEMBL4774224 | 0.71 | ALDH1A1 (0.47) | HRH4BRAFESR1ALDH1A1BLM | |
| SCHEMBL14303803 | 0.69 | MAPT (0.46) | BRAFALDH1A1 | |
| SCHEMBL4796563 | 0.68 | MMP2 (0.46) | ALDH1A1 | |
| SCHEMBL13309932 | 0.67 | HRH4 (0.60) | HRH4ALDH1A1BLML3MBTL1PTGDR | |
| SCHEMBL4776571 | 0.66 | ABCG2 (0.46) | HRH4ESR1ALDH1A1BLML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |