Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.57 |
| ▸ | ESR1 | P03372 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | RPS27 | P42677 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774224 | 0.87 | ALDH1A1 (0.47) | HRH4ESR1ALDH1A1BLML3MBTL1 | |
| SCHEMBL4774760 | 0.83 | HRH4 (0.48) | HRH4ESR1ALDH1A1BLML3MBTL1 | |
| SCHEMBL4774577 | 0.83 | CNR2 (0.51) | HRH4ESR1ALDH1A1BLML3MBTL1 | |
| SCHEMBL4776571 | 0.75 | ABCG2 (0.46) | HRH4ESR1ALDH1A1BLML3MBTL1 | |
| SCHEMBL13309932 | 0.72 | HRH4 (0.60) | HRH4ALDH1A1BLML3MBTL1KDM4E | |
| SCHEMBL14302669 | 0.70 | BRAF (0.47) | HRH4ALDH1A1BLML3MBTL1HRH1 | |
| SCHEMBL13309922 | 0.70 | HRH4 (0.60) | HRH4ALDH1A1BLML3MBTL1 | |
| SCHEMBL4776501 | 0.69 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL17407827 | 0.68 | HRH4 (0.80) | HRH4ALDH1A1HRH1 | |
| SCHEMBL4498447 | 0.67 | PTGDR (0.73) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |