Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | ATP4A | P20648 | 3/20 | 0.40 |
| ▸ | ATP4B | P51164 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20160390 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10RAB9AKMT2A | |
| SCHEMBL19292935 | 0.73 | ALDH1A1 (0.54) | KDM4EALDH1A1PIM1PIM2GRM2 | |
| SCHEMBL29564718 | 0.72 | CTSV (0.51) | KDM4EALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL4866580 | 0.71 | KDM4E (0.79) | KDM4EALDH1A1HSD17B10RAB9AKMT2A | |
| SCHEMBL23895084 | 0.71 | BRD4 (0.46) | ALDH1A1RAB9AKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL11536544 | 0.67 | CDK8 (0.50) | ATP4AATP4BCYP1A2HDAC6TDP1 | |
| SCHEMBL16382563 | 0.67 | BRD4 (0.50) | ALDH1A1ATP4AATP4BRAB9AKMT2A | |
| SCHEMBL11490669 | 0.65 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10RAB9AKMT2A | |
| SCHEMBL4274920 | 0.65 | LMNA (0.55) | ALDH1A1RAB9ASMN1; SMN2CYP1A2HDAC6 | |
| SCHEMBL6219388 | 0.64 | KDM4E (0.73) | KDM4EALDH1A1HSD17B10PIM1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971601-A2 | N4-PHENYL-QUINAZOLINE-4 -AMINE DERIVATIVES AND RELATED COMPOUNDS AS ERBB TYPE I RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | Array Biopharma Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007059257-A2 | N4-PHENYL-QUINAZ0LINE-4 -AMINE DERIVATIVES AND RELATED COMPOUNDS AS ERBB TYPE I RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2007-05-24 | — | — | WO | disclosed |