Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 18/20 | 0.56 |
| ▸ | CTSS | P25774 | 13/20 | 0.56 |
| ▸ | CTSL | P07711 | 11/20 | 0.56 |
| ▸ | CTSB | P07858 | 8/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4129755 | 0.92 | CTSL (0.47) | CTSKCTSSCTSLRXRARXRB | |
| SCHEMBL4039064 | 0.89 | CTSK (0.67) | CTSKCTSSCTSLCTSBPSEN1 | |
| SCHEMBL4310706 | 0.89 | CTSK (0.67) | CTSKCTSSCTSLCTSBPSEN1 | |
| SCHEMBL4309572 | 0.89 | CTSK (0.67) | CTSKCTSSCTSLCTSBPSEN1 | |
| SCHEMBL4775180 | 0.86 | CTSK (0.53) | CTSKCTSSCTSLCTSB | |
| SCHEMBL8350075 | 0.82 | CTSK (0.65) | CTSKCTSSCTSLCTSBRXRA | |
| SCHEMBL7167580 | 0.79 | PTGS2 (0.51) | CTSKCTSS | |
| SCHEMBL7463893 | 0.78 | CTSK (0.64) | CTSKCTSSCTSLCTSBRXRA | |
| SCHEMBL288779 | 0.78 | CTSK (0.53) | CTSKCTSSCTSLCTSBPSEN1 | |
| SCHEMBL6620125 | 0.78 | CTSL (0.54) | CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940785-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007030761-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |
| EP-0983228-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-0983228-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998050342-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |