Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 9/20 | 0.37 |
| ▸ | DRD4 | P21917 | 9/20 | 0.37 |
| ▸ | DRD3 | P35462 | 8/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778365 | 0.84 | PDE5A (0.40) | DRD2DRD4DRD3PDE5AGSK3B | |
| SCHEMBL14303430 | 0.84 | PDE5A (0.40) | DRD2DRD4DRD3PDE5AGSK3B | |
| SCHEMBL4778076 | 0.84 | PDE5A (0.40) | DRD2DRD4DRD3PDE5AGSK3B | |
| SCHEMBL4794991 | 0.83 | ADRA1D (0.43) | GSK3BMEN1ALDH1A1KMT2A | |
| SCHEMBL4774100 | 0.83 | NOS3 (0.42) | DRD2DRD4DRD3PDE5AGSK3B | |
| SCHEMBL4778323 | 0.82 | NOS3 (0.43) | DRD2DRD4DRD3PDE5AGSK3B | |
| SCHEMBL4780410 | 0.77 | NOS3 (0.44) | CYP19A1DRD2DRD4DRD3PDE5A | |
| SCHEMBL4796379 | 0.76 | PDE5A (0.38) | PDE5AKDM4EALDH1A1ADORA1NOS3 | |
| SCHEMBL4776487 | 0.76 | PDE5A (0.38) | PDE5AKDM4EALDH1A1ADORA1NOS3 | |
| SCHEMBL4780443 | 0.76 | PDE5A (0.38) | PDE5AKDM4EALDH1A1ADORA1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |